CD is often missed because its symptoms can suggest so many other diseases. If the doctor is aware of the disease, the diagnosis is made more frequently and missed less often. GPs in Britain and other European countries are familiar with the disease which may account for the apparent increased prevalence in Europe.
The doctor can do blood tests for immune globulins in suspected cases.
IgA - immunoglobulin A
tTGA - anti-tissue transglutaminase
AEA - anti endomysium antibodies
A small bowel biopsy looking for the typical damaged villi follows a positive blood test for confirmation.
In spite of this, some cases will be missed. If the doctor or parent strongly suspects CD it is easy enough to go on a gluten free diet for a week or two. Very severe cases have damage to the small bowel that cannot repair itself, and these will not respond much to a gluten free diet. However most others will see an immediate and spectacular improvement. These patients improve so much that they will not be able to be convinced to go back on gluten as a test.